175347-73-6Relevant academic research and scientific papers
New chiral aminophosphines and their use in asymmetric catalysis
Wimmer,Widhalm
, p. 657 - 660 (1995)
Chiral aminophosphines 4, 5 and 8 were synthesized from 1 in 34%, 57% and 42% overall yield, respectively. The new ligands were investigated with respect to their efficiency in the allylic alkylation of 1,3-diphenyl-1-acetoxy-2-propene with sodium malonate, the cross-coupling reaction of phenethylmagnesium chloride with vinyl bromide, and asymmetric hydrogenations of unsaturated mono- and dicarbonic acids. The highest asymmetric inductions were observed with 4 (dimethyl 1,3-diphenyl-allyl-propandioate, 96% e.e.) and 5 (N-acetylphenylalanine, 77% e.e.; methylsuccinic acid, 56% e.e., 3-phenyl-1-butene 47% e.e.).
Synthesis of Aminophosphines Containing a Chiral Dinaphthoazepine Entity and their Use in Asymmetric Catalysis
Wimmer, P.,Widhalm, M.
, p. 669 - 682 (2007/10/03)
Three azaphospha ligands with a chiral dinaphthoazepine subunit were prepared and used in asymmetric carbon-carbon bond forming reactions.The nickel catalyzed Grignard cross coupling reaction of 1-phenylethyl magnesium chloride and vinyl bromide afforded
