175358-93-7

Upstream product

• 175358-86-8 7-methoxy-2-trimethylsilylbenzofuran-5-carboxylic acid 
• 175358-84-6 7-methoxy-2-trimethylsilylbenzofuran-5-carboxaldehyde 
• 175358-87-9 2-trimethylsilyl-5-(4',4'-dimethyloxazolin-2'-yl)-7-methoxybenzofuran 

Downstream Products

• 175359-00-9 8-Benzyloxy-5,7-dimethoxy-2-trimethylsilanyl-1,12-dioxa-cyclopenta[a]chrysen-13-one 
• 175358-97-1 1-Benzyloxy-11,13-dimethoxy-9-trimethylsilanyl-5,10-dioxa-cyclopenta[b]chrysen-6-one 
• 175358-95-9 1-Benzyloxy-13-hydroxy-11-methoxy-9-trimethylsilanyl-5,10-dioxa-cyclopenta[b]chrysen-6-one 
• 175358-99-3 8-Benzyloxy-7-hydroxy-5-methoxy-2-trimethylsilanyl-1,12-dioxa-cyclopenta[a]chrysen-13-one 

Relevant academic research and scientific papers

Synthesis of defucogilvocarcin V isosteres via MAD-mediated conjugate addition of carbanions to naphthoquinone ketals

Treatment of a complex between naphthoquinone ketal 7 and methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide (MAD) with aryllithium reagents prepared by metallation of oxazoline 13 and amide 18, gave conjugate adducts which were converted to defucogilvocarcin V analogs 2 and 3 via a short reaction sequence. Some problems encountered in the metallation of oxazoline 19, a structural analog of amide 18, are also described.