175359-07-6Relevant academic research and scientific papers
Total synthesis of rhein and diacerhein via a directed ortho metalation of an aromatic substrate
Gonnot, Vanessa,Tisserand, Steve,Nicolas, Marc,Baati, Rachid,Mioskowski, Charles
, p. 7117 - 7119 (2007)
An efficient total synthesis of rhein and diacerhein has been accomplished by relying on a remarkable regioselective directed ortho metalation (DOM) followed by a one-pot two step addition-cyclization reaction, generating phthalide 5 intermediate efficiently.
