17537-48-3

Usage

Structure

Heterocyclic compound with two nitrogen atoms and two carbon atoms

Common Uses

Building block for synthesizing various pharmaceutical compounds
Potential applications in organic electronics and materials chemistry

Specific Applications

Precursor in the synthesis of complex organic compounds

Importance

Vital intermediate in organic synthesis

Upstream product

• 110-13-4 2,5-hexanedione 
• 109-77-3 malononitrile 

Downstream Products

• 1220960-07-5 (Z)-2-amino-5-(1,3-benzodioxol-5-ylmethylene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-16-6 (E)-2-amino-5-(3-bromobenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 340307-50-8 2-amino-4,6-dimethyl-5-(4-methylbenzylidene)-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-19-9 (E)-2-amino-4,6-dimethyl-5-(3-nitrobenzylidene)-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-21-3 (Z)-2-amino-4,6-dimethyl-5-(4-nitrobenzylidene)-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-18-8 (E)-2-amino-4,6-dimethyl-5-(4-nitrobenzylidene)-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-20-2 (Z)-2-amino-5-[4-(4-chlorophenoxy)benzylidene]-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-08-6 (E)-2-amino-5-benzylidene-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-14-4 (Z)-2-amino-5-(2-hydroxybenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-13-3 (E)-2-amino-5-(3-hydroxybenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-15-5 (E)-2-amino-5-(4-bromobenzylidene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-10-0 (Z)-2-amino-5-(biphenyl-4-ylmethylene)-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 
• 1220960-12-2 (Z)-2-amino-5-[4-(dimethylamino)benzylidene]-4,6-dimethyl-5H-cyclopenta[b]pyridine-3,7-dicarbonitrile 

Relevant academic research and scientific papers

5-Substituted [1]pyrindine derivatives with antiproliferative activity

We report herein the synthesis of 5-substituted [1]pyrindine derivatives and the evaluation of their antiproliferative properties on HeLa cells, a cervical carcinoma tumor cell line, and on the melanoma A2058 cell line. The most efficient compounds display cytotoxicity against tumor cells in the micromolar range but have interestingly no effect against the normal human fibroblasts CRL-2796. Generally, these pyrindines are active on both tumor cell lines. Compounds bearing large substituents with structural rigidity at position 5 such as phenyl-furyl show no inhibition of cell growth.