175396-30-2

Basic information

• Product Name: Ethyl 7-oxo-4,5,6,7-tetrahydro-1h-indazole-3-carboxylate
• Synonyms: Ethyl 7-oxo-4,5,6,7-tetrahydro-1h-indazole-3-carboxylate
• CAS NO: 175396-30-2
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.21388
• Mol File: 175396-30-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 451.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.311±0.06 g/cm3(Predicted)
• PKA: 8.84±0.20(Predicted)
• CAS DataBase Reference: Ethyl 7-oxo-4,5,6,7-tetrahydro-1h-indazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 7-oxo-4,5,6,7-tetrahydro-1h-indazole-3-carboxylate(175396-30-2)
• EPA Substance Registry System: Ethyl 7-oxo-4,5,6,7-tetrahydro-1h-indazole-3-carboxylate(175396-30-2)

Safety Data

• Hazardous Substances Data: 175396-30-2(Hazardous Substances Data)

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 802541-12-4 ethyl (3-ethoxy-2-oxocyclohex-3-en-1-yl)-(oxo)acetate 

Downstream Products

• 1382036-85-2 ethyl 1-(4-methoxybenzyl)-7-oxo-4,5 ,6,7-tetrahydro-1H-indazole-3-carboxylate 
• 1382036-86-3 ethyl 2-(4-methoxybenzyl)-7-oxo-4,5,6,7-tetrahydro-2H-indazole-3-carboxylate 

Relevant articles and documents

SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to substituted pyrazolo[4,3-/h]quinazoline compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular PIM kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may