175403-79-9Relevant academic research and scientific papers
Synthesis of 1-p-sulfamylphenyl-3 trifluoromethylpyrazoles class of cyclooxygenase-2 inhibitors
Asiri, Abdullah M.,Faidallah, Hassan M.,Albar, Hassan M.,Sharshira
, p. 483 - 488 (2007/10/03)
Condensation of p-sulfamylphenylhydrazine with diketones 1. afforded pyrazoles 2. Reaction of 2 with isocyanate and isothiocyanate derivatives gave the corresponding ureas 3 and thioureas 4 respectively. Cyclization of the thioureido group of compounds 4 by treating with ethyl bromoacetate, ethyl β-bromopropionate and α-bromoacetophenone afforded the corresponding thiazolidinone, thiazinone and thiazoline derivatives 5, 6 and 7 respectively.
