175416-56-5

Basic information

• Product Name: 2-Morpholinone,3-methoxy-5-(1-methylethyl)-,(3R-cis)-(9CI)
• Synonyms: 2-Morpholinone,3-methoxy-5-(1-methylethyl)-,(3R-cis)-(9CI)
• CAS NO: 175416-56-5
• Molecular Formula: C8H15NO3
• Molecular Weight: 0
• Product Categories: ISOPROPYL
• Mol File: 175416-56-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Morpholinone,3-methoxy-5-(1-methylethyl)-,(3R-cis)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Morpholinone,3-methoxy-5-(1-methylethyl)-,(3R-cis)-(9CI)(175416-56-5)
• EPA Substance Registry System: 2-Morpholinone,3-methoxy-5-(1-methylethyl)-,(3R-cis)-(9CI)(175416-56-5)

Safety Data

• Hazardous Substances Data: 175416-56-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 175226-63-8 (5S)-5-isopropyl-5,6-dihydro-2H-1,4-oxazin-2-one 
• 88362-46-3 (S)-4-isopropyl-2-methyl-Δ²-oxazoline 
• 2026-48-4 (S)-valinol 

Relevant articles and documents

Oxidative rearrangement of 2-substituted oxazolines. A novel entry to 5,6-dihydro-2H-1,4-oxazin-2-ones and morpholin-2-ones

A novel synthesis of 5,6-dihydro-2H-1,4-oxazin-2-ones by SeO2-promoted oxidative rearrangement of 2-alkyl- and 2-(arylmethyl)oxazolines is described. Yields are good to excellent (up to 94%) with the highest yields obtained for 2-arylmethyl- and 2-neopentyl-substituted oxazolines. This reaction provides convenient access to novel 5-aryl-substituted dihydrooxazinones in high yield. The latter compounds are important 'chiral glycine' synthons for asymmetric synthesis of α-amino acids. Since oxazolines are readily derived from carboxylic acids or their equivalents, this oxidative rearrangement constitutes an entry to synthesis of α-amino acids from carboxylic acids. A mechanism is proposed to account for the rearrangement involving a 'nitrilium to acylium' 1,2-migration.