17542-06-2

Usage

Uses

Used in Chemical Synthesis:
2-Iodonaphthalene-1-carboxylic acid is used as a building block for the synthesis of various organic compounds. Its unique structure, which includes an iodine atom and a carboxylic acid group, makes it a valuable intermediate in the preparation of complex molecules.
Used in Organic Chemistry Research:
2-Iodonaphthalene-1-carboxylic acid is used as a research tool in organic chemistry to study the reactivity and properties of naphthalene derivatives. Its acidic and polar nature allows for the investigation of hydrogen bonding and other interactions in chemical systems.
Used in Pharmaceutical Industry:
2-Iodonaphthalene-1-carboxylic acid is used as a starting material for the development of new pharmaceutical compounds. Its structural features can be exploited to design drugs with specific biological activities, such as potential applications in cancer therapy or other therapeutic areas.
Used in Material Science:
2-Iodonaphthalene-1-carboxylic acid is used in the development of new materials with unique properties, such as organic semiconductors or advanced polymers. Its chemical structure can be incorporated into the design of these materials to enhance their electronic, optical, or mechanical properties.

Upstream product

• 148744-41-6 2-iodonaphthalene-1-carboxamide 
• 86-55-5 1-naphthalenecarboxylic acid 
• 86-53-3 1-Cyanonaphthalene 
• 103408-15-7 iodo-2 naphthalene carbonitrile-1 

Downstream Products

• 1357387-71-3 (S)-2-(2-iodonaphthalen-1-yl)-4-isopropyl-1-phenyl-4,5-dihydro-1H-imidazole 
• 1357387-77-9 (S)-2-(2-iodonaphthalen-1-yl)-4-isopropyl-1-tosyl-4,5-dihydro-1H-imidazole 
• 1357387-60-0 C₂₃H₂₃IN₂ 
• 1357387-62-2 C₂₉H₂₇IN₂ 
• 1357387-64-4 C₂₂H₂₇IN₂ 
• 1357387-73-5 C₂₃H₂₃IN₂ 
• 1357387-74-6 C₂₃H₂₃IN₂O 
• 1357387-75-7 C₂₃H₂₀F₃IN₂ 
• 1357387-76-8 C₂₅H₂₇IN₂ 
• 13471-30-2 7H-benzo[a]acridin-12-one 
• 13510-82-2 2-anilino-[1]naphthoic acid 

Relevant academic research and scientific papers

Palladacyclic imidazoline-naphthalene complexes: Synthesis and catalytic performance in Pd(II)-catalyzed enantioselective reactions of allylic trichloroacetimidates

A new family of air- and moisture-stable enantiopure C,N-palladacycles (PIN-acac complexes) were prepared in good overall yield in three steps from 2-iodo-1-naphthoic acid and enantiopure β-amino alcohols. Three of these PIN complexes were characterized by single-crystal X-ray analysis. As anticipated, the naphthalene and imidazoline rings of PIN-acac complexes 18a and 18b were canted significantly from planarity and projected the imidazoline substituents R1 and R2 on opposite faces of the palladium square plane. Fifteen PIN complexes were evaluated as catalysts for the rearrangement of prochiral (E)-allylic trichloroacetimidate 19 (eq 2) and the SN2′ allylic substitution of acetic acid with prochiral (Z)-allylic trichloroacetimidate 23. Although these complexes were kinetically poor catalysts for the Overman rearrangement, they were good catalysts for the allylic substitution reaction, providing branched allylic esters in high yield. However, enantioselectivities were low to moderate and significantly less than that realized with palladacyclic complexes of the COP family. Computational studies support an anti-acetoxypalladation/syn-deoxypalladation mechanism analogous to that observed with COP catalysts. The computational study further suggests that optimizing steric influence in the vicinity of the carbon ligand of a chiral C,N-palladacycle, rather than near the nitrogen heterocycle, is the direction to pursue in future development of improved enantioselective catalysts of this motif.

Controlling chemoselectivity in reactions of unprotected naphthalene-1-carboxylic acid with strong bases

Whereas treatment of unprotected naphthalene-1-carboxylic acid with alkyllithiums (RLi) affords 1,4-addition products, the reaction with LTMP/Me3SiCl under in situ quench conditions provides the arylsilane arising out from the substitution of l

Iodosonaphthoate catalysts for the cleavage of a reactive phosphate

Iodosonaphthoates 3-5 are potent catalysts for the hydrolysis of P-nitro-phenyldiphenyl phosphate.