17543-50-9

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 

Downstream Products

• 127292-71-1 (S)-2-{(S)-2-[(S)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyric acid 
• 169625-84-7 N-benzyloxycarbonyl-(S)-tryptophan piperidine amide 
• 76927-13-4 N^α-Z-L-tryptophyl-L-alanyl-glycyl-glycine 
• 169869-68-5 <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid 
• 169869-69-6 <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylic acid 
• 160557-08-4 methyl <4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate 
• 160557-09-5 methyl <4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazole-4(5)-carboxylate 
• 160557-10-8 <<4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 160637-58-1 <<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 169869-60-7 <<4(5)R>-2-<1(S)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 169869-62-9 <<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide 
• 160637-55-8 N-benzyloxycarbonyl-(S)-tryptophan piperidine thioamide 

Relevant academic research and scientific papers

TACHYKININ ANTAGONISTS

The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.

Synthesis of A Homochiral α,α-Disubstituted α,β-Diamino-acid

The synthesis of a homochiral α,α-diamino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-