17543-97-4

Upstream product

• 504-29-0 2-aminopyridine 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 70301-52-9 2-<(o-hydroxybenzyl)amino>pyridine 

Relevant academic research and scientific papers

Synthesis and inhibitive performance of novel cationic and gemini surfactants on carbon steel corrosion in 0.5 M H2SO4 solution

Novel cationic and gemini surfactants were synthesized and characterized. The corrosion inhibition efficiency of the synthesized surfactants was studied, on carbon steel in 0.5 M H2SO4, by weight loss, potentiodynamic polarization an

Rh(III)-Catalyzed imidoyl C-H carbamylation and cyclization to bicyclic [1,3,5]triazinones

A Rh(III)-catalyzed synthesis of bicyclic [1,3,5]-triazinones from a diverse array of imines coupled with ethyl (pivaloyloxy)carbamate is reported. The preparation of [5,6]- and [6,6]-bicyclic heterocycles substituted with aryl, alkyl, and alkoxy groups demonstrated a broad reaction scope. The efficiency of this approach was further enhanced with the development of a three-component variant featuring in situ imine formation. X-ray crystallographic characterization of a rhodacycle formed by imidoyl C-H activation provides support for the proposed mechanism.

Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

In this study, five novel complexes for Co(II), Ni(II), VO(II), Cr(III), and La(III) ions were synthesized from a tridentate NNO monobasic chelating Schiff base ligand, (Z)-2-((pyridin-2-ylimino)methyl)phenol (HL). Spectral and analytical tools were applied to elucidate the structural compositions of the new compounds. Then, geometry optimization was conducted for all the syntheses by the Gaussian 09 program via the density functional theory method to obtain optimal structures and the most essential parameters. Moreover, the biochemical behaviors of all the syntheses were explored based on the reactivity, which was tested against various cancer cell lines (HepG-2, MCF-7, and HCT-116). The complexes exhibited an interestingly antiproliferative potential against human cancer cell lines, and the cytotoxicities of the new complexes were arranged to follow the order: VOL > CrL > NiL > LaL > CoL > HL. The antioxidant behaviors of the complexes were studied using the DPPH assay, and VOL showed the maximum antioxidant activity, followed by LaL. The antibacterial activities of the HL ligand and its complexes were studied. Moreover, the binding nature of the complexes with calf thymus DNA (CT-DNA) was investigated based on the spectrophotometric absorption titration, viscosity, and gel electrophoresis methods. The binding ability of the complexes with CT-DNA was proposed to be just intercalation or replacement mode. The intrinsic binding constant Kb was calculated and arranged based on the following order: VOL (5.2 × 105) > CrL (3.6 × 105) > NiL (3.3 × 105) > LaL (3.0 × 105) > CoL (1.12 × 105) mol?1?dm?3. Docking investigations were performed using the receptors of COVID-19's main protease viral protein (PDB ID: 6LU7) and Escherichia coli (gram [–ve] bacteria [PDB ID: 1fj4]).

Synthesis and biological activity of some 3-aryl-3,4-dihydro-2h-benz[e]-1, 3-oxazines/6-bromo-3-aryl-3,4-dihydro-2h-benz[e]-1,3-oxazines

N-(2-Hydroxy)-benzyl-arylamine (1) gives substantially pure 3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines/6-bromo-3-aryl-3,4-dihydro-2H-benz[e] -1,3-oxazines (2) on cyclization with formaldehyde in methanol within 0.5-1.0 h at 65-68 C in excellent yields. Th

Synthesis, spectral studies of salicylidine-pyridines: Crystal and molecular structure of 2-[(1E)-2-aza-2-(5-methyl(2-pyridyl)ethenyl)]-4-bromobenzen-1-ol

Schiff bases derived from different meta-substituted salicylaldehyde and 5-methylaminopyridine have been synthesized and characterized by elemental analysis, FT-IR, NMR and UV-vis techniques. NMR assignments were made using 1H, 13C N

Studies on some salicylaldehyde Schiff base derivatives and their complexes with Cr(III), Mn(II), Fe(III), Ni(II) and Cu(II)

The formation constants of some transition metal ions Cr(III), Mn(II), Fe(III), Ni(II) and Cu(II) binary complexes containing Schiff bases resulting from condensation of salicylaldehyde with aniline (I), 2-aminopyridine (II), 4-aminopyridine (III) and 2-aminopyrimidine (IV) were determined pH-metrically in ethanolic medium (80%, v/v). The formation constants were determined for all binary complexes. The important infrared (IR) spectral bands corresponding to the active groups in the four ligands and the solid complexes under investigation were studied. The solid complexes have been synthesized and studied by thermogravimetric analysis. The thermal dehydration and decomposition of these complexes were studied kinetically using the integral method applying the Coats-Redfern equation. It was found that the thermal decomposition of the complexes follow second order kinetics. The thermodynamic parameters of the decomposition are also reported. The electronic absorption spectra of the investigated ligands were carried out to determine the pKa values spectrophotometrically.

Synthesis, spectra, redox property and catalytic activity of ruthenium(III) Schiff base complexes

A series of ruthenium(III) complexes of the type [RuX2(EPh 3)2(L)] (where E= P or As, X= Cl or Br; L = bidentate Schiff bases) have been synthesized and characterized on the basis of analytical (elemental analysis, magnetic susceptibility) and spectral methods (FT-IR, UV-vis, EPR). EPR spectra of the powdered samples exhibit three lines with different 'g' values indicating a rhombic distortion in these complexes. Cyclic voltammogram of the complexes displays one reversible oxidation (Ru IV/RuIII) and two reversible reduction peaks (Ru III/RuII, RuII/RuI) with ΔEP=60-80 mV suggesting one electron transfer process. These complexes effectively catalyze the oxidation of primary alcohols to their corresponding aldehydes up to 91.5% in the presence of N-methylmorpholine-N- oxide (NMO) as co-oxidant. The formation of high-valent Run+2=O species as catalytic intermediate is proposed for the catalytic processes.

Hydrogen Bonding and Tautomeric Equilibria in Schiff Bases Derived from 2-Aminopyridines: Electronic Spectral Evidence for Substituent Effects

Schiff bases of the type C6H3(R)(OH)CH=NC5H3N(Y) have now been synthesised and evidence sought for th