175444-86-7

Basic information

• Product Name: [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester
• Synonyms: [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester
• CAS NO: 175444-86-7
• Molecular Weight: 363.457
• Mol File: 175444-86-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester(175444-86-7)
• EPA Substance Registry System: [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester(175444-86-7)

Safety Data

• Hazardous Substances Data: 175444-86-7(Hazardous Substances Data)

Upstream product

• 20902-47-0 N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester 
• 13734-41-3 t-Boc-L-valine 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 

Relevant articles and documents

Serine- and threonine-derived diamine equivalents for site-specific incorporation of platinum centers in peptides, and the anticancer potential of these conjugates

A modular strategy that allows introduction of one or more reactive platinum units at chosen locations along a peptide sequence is presented. This makes use of diazides generated from serine and threonine as diamine equivalents which can be conjugated to the peptide under standard coupling conditions. Reduction of these diazides using Pd/C and H2 followed by platination affords the final products in good yields. Following this, we prepared a new class of peptide-platinum conjugates and carried out preliminary cytotoxicity evaluation and DNA interaction studies. Inclusion of lysine residues in the sequence was found to improve DNA interaction and anticancer activities compared to analogous conjugates with hydrophobic side chains.