175476-72-9

Upstream product

• 175476-71-8 3-(2-Methoxy-biphenyl-3-yl)-[1,1']binaphthalenyl-2,2'-diol 
• 175476-70-7 3-(2-Methoxy-biphenyl-3-yl)-2,2'-bis-methoxymethoxy-[1,1']binaphthalenyl 
• 142010-72-8 3-Bromo-2,2'-bis-methoxymethoxy-[1,1']binaphthalenyl 

Downstream Products

• 175476-76-3 (C₂₆H₁₄O₃)H(C₆H₅)B(C₆H₃(CF₃)2) 

Relevant academic research and scientific papers

Design of bronsted acid-assisted chiral Lewis acid (BLA) catalysts for highly enantioselective Diels-Alder reactions

Bronsted acid-assisted chiral Lewis acid (BLA) was highly effective as a chiral catalyst for the enantioselective Diels-Alder reaction of both α- substituted and α-unsubstituted α,β-enals with various dienes. Hydroxy groups in optically active binaphthol derivatives and boron reagents with electron-withdrawing substituents were used as Bronsted acids and Lewis acids, respectively. Intramolecular Bronsted acids in a chiral BLA catalyst played an important role in accelerating the rate of Diels-Alder reactions and in producing a high level of enantioselectivity. In particular, excellent enantioselectivity was achieved due to intramolecular hydrogen bonding interaction and attractive π-π donor-acceptor interaction in the transition-state assembly by hydroxy aromatic groups in a chiral BLA catalyst.