175481-39-7

Basic information

• Product Name: Desacetyl DesMethyl LacosaMide
• Synonyms: Desacetyl DesMethyl LacosaMide
• CAS NO: 175481-39-7
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• Mol File: 175481-39-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Desacetyl DesMethyl LacosaMide(CAS DataBase Reference)
• NIST Chemistry Reference: Desacetyl DesMethyl LacosaMide(175481-39-7)
• EPA Substance Registry System: Desacetyl DesMethyl LacosaMide(175481-39-7)

Safety Data

• Hazardous Substances Data: 175481-39-7(Hazardous Substances Data)

Usage

Uses

Desacetyl Desmethyl Lacosamide is an impurity of Lacosamide (L098500) which is a potent anticonvulsant.

Upstream product

• 3262-72-4 (R)-N-tert-butoxycarbonyl serine 
• 100-46-9 benzylamine 
• 1322062-75-8 (2R)-2-amino-N-benzyl-3-hydroxypropanamide hydrochloride 
• 1357171-70-0 (2S)-N-benzyl-2-bromo-3-hydroxypropanamide 
• 1357171-71-1 (2R)-2-azido-N-benzyl-3-hydroxypropanamide 
• 1253790-58-7 tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate 
• 312-84-5 D-Serine 
• 219835-31-1 (R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 

Downstream Products

• 175481-36-4 lacosamide 
• 1253790-58-7 tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate 
• 196601-69-1 (R)-2-amino-N-benzyl-3-methoxypropanamide 
• 175481-38-6 Desmethyllacosamide 
• 1320360-92-6 (R)-N-benzyl-2-(ethoxycarbonylamino)-3-methoxypropionamide 
• 1320360-91-5 (R)-N-benzyl-2-(ethoxycarbonylamino)-3-hydroxypropionamide 

Relevant articles and documents

Method for preparing lacosamide by microreactor

The invention discloses a method for preparing lacosamide by a microreactor. According to the method, D-serine is used as a starting raw material to take a condensation reaction with aniline for obtaining a compound I; then, methylation reaction is performed with a methylation reagent to obtain a compound II; then, acetylation reaction is performed with an acetylation reagent to obtain the lacosamide; the at least methylation reaction is performed in the microreactor. Compared with a conventional method, the method provided by the invention has the advantages that the protection is not needed on the amidogen of the D-serine; the synthesis route is reduced from the five-step reaction to the three-step reaction; the reaction steps are greatly simplified; meanwhile, the reaction conditions are mild; the safety is high; the environment-friendly effect is good; the byproducts in each step are few; the product yield is high; the method is suitable for industrial production. The formulas are shown as the accompanying drawing.

LACOSAMIDE INTERMEDIATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF

A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved.

PROCESS FOR PREPARATION OF LACOSAMIDE AND SOME N-BENZYL-PROPANAMIDE INTERMEDIATE DERIVATIVES

The present invention discloses novel process for the preparation of (2R)-2-acetamido-N- benzyl-3-methoxypropanamide of Formula I involving novel intermediates of Formula - XIX and Formula - XX.