175531-13-2

Basic information

• Product Name: tert-butyl 2-(broMoMethyl)-1H-benzo[d]iMidazole-1-carboxylate
• Synonyms: tert-butyl 2-(broMoMethyl)-1H-benzo[d]iMidazole-1-carboxylate;1-BOC-2-bromomethylbenzimidazole;tert-Butyl 2-(bromomethyl)-1H-benzimidazole-1-carboxylate
• CAS NO: 175531-13-2
• Molecular Formula: C13H15BrN2O2
• Molecular Weight: 311.1744
• Mol File: 175531-13-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-(broMoMethyl)-1H-benzo[d]iMidazole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(broMoMethyl)-1H-benzo[d]iMidazole-1-carboxylate(175531-13-2)
• EPA Substance Registry System: tert-butyl 2-(broMoMethyl)-1H-benzo[d]iMidazole-1-carboxylate(175531-13-2)

Safety Data

• Hazardous Substances Data: 175531-13-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 175531-34-7 tert-butyl 2-methyl-1H-benzo[d]imidazole-1-carboxylate 

Downstream Products

• 58758-09-1 (E)-2-styryl-1H-benzo[d]imidazole 

Relevant articles and documents

Reaction of bromomethylazoles and tosylmethyl isocyanide. A novel heterocyclization method for the synthesis of the core of marine alkaloids variolins and related azolopyrimidines

A novel and efficient synthesis of the pyrido[3′,2′:4,5] pyrrolo[1,2-c]pyrimidine system, the heterocyclic core of the variolin family of marine alkaloids, is described. The route involves the reaction of 3-bromo-2-(bromomethyl)pyrrolo[2,3-b]pyridine and tosylmethyl isocyanide (TosMIC) under phase-transfer conditions. This unprecedented reaction was also used to synthesize a series of new methoxycarbonyl azolopyrimidines by reaction of TosMIC with bromomethylindoles, bromomethylbenzimidazole, and bromomethylpyrazole. Hydrolysis and decarboxylation of 5-bromo-7- methoxycarbonylpyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine obtained by this heterocyclization process and installation of the pyrimidine moiety in the C5 position open an alternative approach to complete a total synthesis of variolin B.

Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity

Vitronectin receptor antagonists having the formula: STR1 which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.