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175591-23-8

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175591-23-8 Usage

Uses

Analgesic (μ-agonist).

Pharmacology

Tapentadol, a relatively new opioid, also has distinct mechanisms of analgesic action. It is a MOP receptor agonist more potent than tramadol. It also acts by selectively inhibiting reuptake of noradrenaline, and therefore there may be a rationale for using it in patients with pain with neuropathic features.

Check Digit Verification of cas no

The CAS Registry Mumber 175591-23-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,5,9 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175591-23:
(8*1)+(7*7)+(6*5)+(5*5)+(4*9)+(3*1)+(2*2)+(1*3)=158
158 % 10 = 8
So 175591-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3

175591-23-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol

1.2 Other means of identification

Product number -
Other names TAPAL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175591-23-8 SDS

175591-23-8Relevant articles and documents

PROCESS FOR THE PREPARATION OF TAPENTADOL AND ANALOGS THEREOF

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Page/Page column 6; 15-16, (2020/10/17)

The present invention relates to a process for the preparation of tapentadol and analogs or compounds or stereoisomers of formula (I), Formula I wherein, A is aryl, heteroaryl, and cycloalkyl; R is H, OH, OR1, halogen, C1-C12 alkyl, cycloalkyl, aryl or heteroaryl; R1 is C1-C12 alkyl, cycloalkyl, aryl or heteroaryl, wherein each of these groups may further be substituted with one or more substituent selected from H, OH, halogen, CN, NO2, C1-C4 alkyl or phenyl. Further, the multi-step process involves no column chromatography purification until the very last step. This makes this process highly commercially viable and industrially useful.

TWO-STEP PROCESS FOR PREPARING 3-SUBSTITUTED PHENYLALKYLAMINES

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, (2017/01/31)

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

PROCESS FOR PREPARING SUBSTITUTED PHENYLALKANES

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Paragraph 0170, (2016/01/25)

The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.