175612-35-8

Basic information

• Product Name: C₆₀H₁₀₄O₁₂Si₂
• Synonyms: C₆₀H₁₀₄O₁₂Si₂
• CAS NO: 175612-35-8
• Molecular Weight: 1073.65
• Mol File: 175612-35-8.mol

Chemical Properties

• CAS DataBase Reference: C₆₀H₁₀₄O₁₂Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₀H₁₀₄O₁₂Si₂(175612-35-8)
• EPA Substance Registry System: C₆₀H₁₀₄O₁₂Si₂(175612-35-8)

Safety Data

• Hazardous Substances Data: 175612-35-8(Hazardous Substances Data)

Upstream product

• 59983-36-7 (S)-1-(1-Ethylpropylidenamino)-2-methoxymethylpyrrolidin 
• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-rhamnopyranose 
• 175612-30-3 C₆₂H₁₁₂O₁₁Si₃ 
• 175612-33-6 C₅₇H₁₀₂O₁₁Si₂ 
• 180592-85-2 Benzoic acid (1R,2S,3S,4S)-1-((1R,2S)-2,3-bis-benzyloxy-1-methyl-propyl)-3-hydroxy-6-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-2,4-dimethyl-hexyl ester 
• 175612-28-9 Benzoic acid (1R,2R,3S,4S)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(R)-1-((S)-2,2-dioxo-2λ⁶-[1,3,2]dioxathiolan-4-yl)-ethyl]-6-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-2,4-dimethyl-hexyl ester 
• 180592-94-3 Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester 
• 180592-93-2 Benzoic acid (2S,3S)-4-[(2S,6R)-6-((E)-(S)-2-hydroxy-5-methoxycarbonyl-hex-4-enyl)-3,6-dihydro-2H-pyran-2-yl]-3-methoxy-2-methyl-butyl ester 
• 180592-91-0 Benzoic acid (2S,3S)-3-methoxy-2-methyl-4-[(2S,6R)-6-(2-oxo-ethyl)-3,6-dihydro-2H-pyran-2-yl]-butyl ester 
• 180592-90-9 Benzoic acid (2S,3S)-4-((2S,6R)-6-allyl-3,6-dihydro-2H-pyran-2-yl)-3-methoxy-2-methyl-butyl ester 
• 180592-87-4 (4R,6S)-4-Iodomethyl-6-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-[1,3]dioxan-2-one 
• 180592-88-5 (2S,3S)-4-(4-Methoxy-benzyloxy)-3-methyl-1-(R)-oxiranyl-butan-2-ol 
• 180592-86-3 (2S,3S)-1-(4-methoxybenzyloxy)-2-methylhex-5-en-3-ol 
• 180592-89-6 (-)-(2S,3S)-4-((2S,6R)-6-allyl-3,6-dihydro-2H-pyran-2-yl)-3-methoxy-2-methylbutan-1-ol 

Downstream Products

• 180593-05-9 C₅₉H₁₀₀O₁₁Si₂ 
• 175612-36-9 C₅₉H₁₀₂O₁₂Si₂ 

Relevant articles and documents

Total Synthesis of Swinholide A, Preswinholide A, and Hemiswinholide A

The total synthesis of swinholide A (1) has been accomplished via key intermediate aldehyde 12 (Fig. 3), whose construction started from L-rhamnose (18), epoxide 21, and phenylsulfone orthoester 22, and proceeded through an Enders asymmetric alkylation (16 + 17 -> 15), a Ghosez cyclization (21 + 22 -> 20), and a Corey-Sharpless coupling reaction (13 + 14 -> 12).Elaboration of compound 12 along slightly different pathways culminated in the synthesis of carboxylic acid 10 and hydroxy compound 11, whose union by an esterification reaction, followed by ring closure of the subsequently derived hydroxy acid under Yamaguchi conditions, led to swinholide A (1) upon deprotection.The chemistry developed also allowed the total synthesis of preswinholide A methyl ester (7), preswinholide A (8), and hemiswinholide A (78).Keywords: natural products; swinholide A; total syntheses