175650-97-2

Upstream product

• 55474-11-8 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate 
• 175651-04-4 2',3',5'-tri-O-acetyl-4-O-methyl-5-fluorouridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 175651-05-5 4-O-methyl-5-fluorouridine 

Downstream Products

• 175650-98-3 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-5-fluoro-4-methoxy-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

19F NMR of RNA. The structural and chemical aspects of 5-fluoro-cytidine and -uridine labelling of oligoribonucleotides

Results of PM3 semiempirical calculation revealed that energy and hydrogen bonds geometry of 1-methyl-5-fluoro-uracil and -cytosine base-pairs with 9-methyladenine and -guanine respectively are virtually the same as for the natural bases. Analysis of proton coupling constants proved that the sugar puckering of 5-fluorouridine and 5-fluorocytidine is analogous to non-modified ribonucleosides. 5-Fluorocytidine was regioselectively introduced to oligoribonucleotides, prepared using 2'-O-tert-dimethylsilyl protection, via post-synthetic quantitative ammonolysis of 4-O-methyl-5-fluorouridine derived precursor.