175659-83-3Relevant academic research and scientific papers
Diastereoselective alkylation of homochiral 1,2,3,4-tetrahydroisoquinolin-3-one. A potential route to enantiomerically pure 4-substituted tetrahydroisoquinolines
Philippe, Nicolas,Levacher, Vincent,Dupas, Georges,Duflos, Jack,Queguiner, Guy,Bourguignon, Jean
, p. 417 - 420 (1996)
Enantiomerically pure 1,4-dihydroisoquinolin-3-one 1 was prepared in four steps with an overall yield of 60%. Alkylation of the corresponding lactam enolate has been studied and has proven to be highly diastereoselective. Thus, 4-substituted-1,4-dihydroisoquinolin-3-ones 7a-d were obtained in high chemical yields with up to 97% diastereoisomeric excesses.
