175663-01-1

Upstream product

• 175662-99-4 (E)-(4R,5R)-5-((R)-2-tert-Butoxycarbonylamino-propionyloxy)-4,6-dimethyl-hept-2-enoic acid 2-trimethylsilanyl-ethyl ester 
• 105183-57-1 2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester 
• 105228-55-5 2-[(4R,6S)-6-((E)-2-Methyl-3-oxo-propenyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester 
• 105228-53-3 2-[(4R,6S)-6-Hydroxymethyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester 
• 105228-54-4 2-[(4R,6S)-6-Formyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester 
• 97522-38-8 2(S)-methyl-3(R)-hydroxy-4-methylpentanal 
• 77877-21-5 (4S)-3-((2S,3R)-3-hydroxy-2,4-dimethyl-1-oxopentyl)-4-(1-methylethyl)-2-oxazolidinone 
• 64761-29-1 mesitaldehyde dimethylacetal 
• 175663-00-0 (E)-(4R,5R)-5-((R)-2-Amino-propionyloxy)-4,6-dimethyl-hept-2-enoic acid 2-trimethylsilanyl-ethyl ester 

Downstream Products

• 175663-03-3 (E)-(4R,5R)-5-[(R)-2-({2-[(4R,6S)-6-((1E,3E)-5-Amino-2-methyl-penta-1,3-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carbonyl}-amino)-propionyloxy]-4,6-dimethyl-hept-2-enoic acid 
• 175663-04-4 (14E,19E,21E)-(1R,9R,12R,13R,23S)-12-Isopropyl-9,13,21-trimethyl-25-(2,4,6-trimethyl-phenyl)-4,11,24,26-tetraoxa-8,17,28-triaza-tricyclo[21.3.1.1^3,6]octacosa-3⁽²⁸⁾,5,14,19,21-pentaene-7,10,16-trione 
• 175663-02-2 (E)-(4R,5R)-5-[(R)-2-({2-[(4R,6S)-6-((1E,3E)-5-Amino-2-methyl-penta-1,3-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carbonyl}-amino)-propionyloxy]-4,6-dimethyl-hept-2-enoic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

Total synthesis of streptogramin antibiotics. (-)-Madumycin II

Synthetic efforts toward members of the streptogramin group A compounds have been reported over the past 15 years and to date none have succeeded in reaching any of the targets. We now report the first enantioselective total synthesis of Madumycin II (A-2