175689-33-5

Basic information

• Product Name: tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate
• Synonyms: tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate
• CAS NO: 175689-33-5
• Molecular Weight: 197.234
• Mol File: 175689-33-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate(175689-33-5)
• EPA Substance Registry System: tert-butyl 2-(hydroxymethyl)-1H-pyrrole-1-carboxylate(175689-33-5)

Safety Data

• Hazardous Substances Data: 175689-33-5(Hazardous Substances Data)

Upstream product

• 5176-27-2 N-tert-butyloxycarbonyl-pyrrole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 1003-29-8 2-pyrrole aldehyde 
• 161282-57-1 N-tert-butoxycarbonylpyrrole-2-carboxaldehyde 

Downstream Products

• 1582256-43-6 tert-butyl 2-(4-amino-3-chlorobenzyl)-1H-pyrrole-1-carboxylate 
• 175689-41-5 <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate 
• 295800-89-4 2-ethoxycarbonyl-3-(3-iodophenyl)-11-N-(tert-butoxycarbonyl)dipyrromethane 
• 238760-84-4 2-ethoxycarbonyl-3-(4-iodophenyl)-11-N-(tert-butoxycarbonyl)dipyrromethane 
• 175689-39-1 <1-(1,1-dimethylethoxycarbonyl)-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate 

Relevant articles and documents

Benzonorbornadiene Derivatives and Reactions Thereof

A bioorthogonal molecule can include a molecule having a structure according the above wherein R1-R8 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, COOH, COORsu

Palladium-catalyzed regioselective allylation of five-membered heteroarenes with allyltributylstannane

Palladium-catalyzed allylation reactions of 2-(chloromethyl)thiophenes, 2-(chloromethyl)furans, and N-protected 2-(chloromethyl)-1H-pyrroles with allyltributylstannane were described in this study. This type of allylation reaction regioselectively occurred on the heteroarene rings to produce allylated dearomatization products or allylated heteroarenes with satisfactory yields.

INHIBITORS OF DIPEPTIDYLPEPTIDASE IV

The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods of using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the P1 and/or P2 position of the inhibitor that contain a carboxylic acid moiety. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.