175694-15-2Relevant academic research and scientific papers
Compounds for the Treatment of Hepatitis C
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, (2008/12/07)
The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands
Hudack Jr., Raymond A.,Barta, Nancy S.,Guo, Chuangxing,Deal, Judith,Dong, Liming,Fay, Lorraine K.,Caprathe, Bradley,Chatterjee, Arindam,Vanderpool, Darin,Bigge, Christopher,Showalter, Richard,Bender, Steve,Augelli-Szafran, Corinne E.,Lunney, Elizabeth,Hou, Xinjun
, p. 1202 - 1206 (2007/10/03)
Since the discovery that FK-506 promotes neurite outgrowth, considerable attention has been focused on the development of potent nonimmunosuppressive ligands for FK-506 binding proteins (FKBPs). Such neuroimmunophilin agents have been reported to show neu
Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation
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, (2008/06/13)
Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic az
