175698-02-9Relevant academic research and scientific papers
Anticonvulsant and anxiolytic lactam and thiolactam derivatives
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, (2008/06/13)
This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.
3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: A new class of anticonvulsant agents
Reddy, P. Amruta,Hsiang, Bonnie C. H.,Latifi, Tammy N.,Hill, Matthew W.,Woodward, Karen E.,Rothman, Steven M.,Ferrendelli, James A.,Covey, Douglas F.
, p. 1898 - 1906 (2007/10/03)
A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2- pyrrolidinones (lactams) have been prepared and evaluated for their anticonvulsant activities. In the pentylenetetrazole mouse seizure model, 3,3-diethyl lactam 7c and 3-benzyl-3-ethyl lactam 7j
