17570-08-0Relevant academic research and scientific papers
Early Development Scale-Up of a Novel CXCR Antagonist: Focus on Racemic and Stereoselective Routes of a Key Intermediate
Tabet, Samuel,Rodeville, Nicolas,Mathieu, Arnaud,Raffin, Catherine,Millois-Barbuis, Corinne,Musicki, Branislav,Muller, Franck,Gerfaud, Thibaud,Boiteau, Jean-Guy,Cardinaud, Isabelle
, p. 2032 - 2044 (2017)
Efforts toward a convenient and scalable process for the synthesis of a novel CXCR antagonist 1 are described, with a specific focus on a chiral key intermediate. Two generations of a racemic route have been developed for short-term deliveries, and a ster
Process for the preparation of optically active carboxylic acids and amide intermediates
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, (2008/06/13)
The present invention provides a process for the preparation of optically active carboxylic acids of the formula I* or II* STR1 in which X is an oxygen or sulfur atom and n is 1 or 2. The process comprises reacting a racemic carboxylic acid I or II or its derivatives with an optically active 2-amino-carboxylic acid ester to give the diastereomeric carboxylic acid amides, separating the diastereomers and, after cleavage of the amide bond, isolating the optically active carboxylic acids of the general formula I* or II*. The invention also provides certain novel optically active carboxylic acid amides and a tetrahydrothiopyran-2-carboxylic acid.
