175702-33-7

Basic information

• Product Name: 2(1H)-Pyridinethione, 5,6-dihydro-6-(hydroxymethyl)-, (S)- (9CI)
• Synonyms: 2(1H)-Pyridinethione, 5,6-dihydro-6-(hydroxymethyl)-, (S)- (9CI)
• CAS NO: 175702-33-7
• Molecular Formula: C6H9NOS
• Molecular Weight: 143.20676
• Product Categories: ALDEHYDE
• Mol File: 175702-33-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 246.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 11.50±0.40(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinethione, 5,6-dihydro-6-(hydroxymethyl)-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinethione, 5,6-dihydro-6-(hydroxymethyl)-, (S)- (9CI)(175702-33-7)
• EPA Substance Registry System: 2(1H)-Pyridinethione, 5,6-dihydro-6-(hydroxymethyl)-, (S)- (9CI)(175702-33-7)

Safety Data

• Hazardous Substances Data: 175702-33-7(Hazardous Substances Data)

Usage

Derived from

Pyridinethione

Use

Anti-dandruff shampoos and other hair care products

Active enantiomer

(S)-

Mechanism of action

Inhibits the growth of fungi

Efficacy

Good as an antifungal agent

Additional uses

Treatment of fungal infections on the skin and scalp in personal care products and pharmaceuticals.

Upstream product

• 1026229-00-4 (S)-2-Benzoyloxymethyl-6-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 1026261-78-8 (S)-2-Benzoyloxymethyl-6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 175609-09-3 Benzoic acid (S)-6-oxo-piperidin-2-ylmethyl ester 
• 175609-11-7 Benzoic acid (S)-6-oxo-1,2,3,6-tetrahydro-pyridin-2-ylmethyl ester 
• 128726-47-6 (+)-(S)-6-hydroxymethyl-2-piperidinone 
• 175609-12-8 (S)-(-)-3,4-dehydro-6-benzoyloxymethyl-2-thiopiperidinone 

Relevant articles and documents

Inhibition of mouse tumor metastasis with nojirimycin-related compounds

The antimetastatic activity of ten compounds structurally related to nojirimycin A was examined using a pulmonary metastatic model of mouse B16 melanoma. Nojirimycin B, deoxynojirimycin, D-gluco-δ-lactam, CP3068 and CP3069 are structural analogues of nojirimycin A, and showed potent or moderate antimetastatic activities. Nojirimycin A, nojirimycin B, deoxynojirimycin and D-gluco-δ-lactam showed potent or moderate inhibitory activities against α-glucosidase, β-glucosidase and β-mannosidase, but CP3068 and CP3069 in which the structures were related to D-gluco-δ-lactam showed no inhibitory activities. CP3041, CP3042, CP3043, CP3045 and CP3048 are analogues of sodium D-glucaro-δ-lactam (ND2001), a carboxy derivative of nojirimycin A, and showed potent or moderate antimetastatic activities. But no analogue was superior to ND2001 concerning with antimetastatic and anti-β-glucuronidase activities. CP3041 and CP3042 showed potent and moderate inhibitory activities against β-glucuronidase, respectively, but CP3043, CP3045 and CP3048 showed little or no activities.