17571-47-0Relevant academic research and scientific papers
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation
Yushchenko, Dmytro A.,Fauerbach, Jonathan A.,Thirunavukkuarasu, Shyamala,Jares-Erijman, Elizabeth A.,Jovin, Thomas M.
, p. 7860 - 7861 (2010)
We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of α-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of α-synuclein aggregation, a process associated with Parkinsons disease.
