175711-83-8

Basic information

• Product Name: 4''-CHLORO-2''-FLUOROACETOPHENONE
• Synonyms: 1-(4-Chloro-2-fluorophenyl)ethanone;4-Chloro-2-fluoroacetophenone;1-(4-Chloro-2-fluorophenyl)ethan-1-one
• CAS NO: 175711-83-8
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.585
• Product Categories: Adehydes, Acetals & Ketones;Chlorine Compounds;Fluorine Compounds;Fluorine series
• Mol File: 175711-83-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 233 ºC
• Flash Point: 95 ºC
• Appearance: /
• Density: 1.258
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4''-CHLORO-2''-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4''-CHLORO-2''-FLUOROACETOPHENONE(175711-83-8)
• EPA Substance Registry System: 4''-CHLORO-2''-FLUOROACETOPHENONE(175711-83-8)

Safety Data

• Hazardous Substances Data: 175711-83-8(Hazardous Substances Data)

Usage

Uses

4''-Chloro-2''-fluoroacetophenone is used as a reagent in the synthesis of aminoazabenzimidazoles as a novel class of orally active antimalarial agents. 4''-Chloro-2''-fluoroacetophenone is also used in the preparation of the JAK2 Inhibitor, LY2784544 (L486570).

Upstream product

• 99-91-2 para-chloroacetophenone 
• 112279-56-8 1-(4-amino-2-fluorophenyl)ethanone 
• 351-28-0 N-(3-fluorophenyl)acetamide 
• 372-19-0 meta-fluoroaniline 
• 198967-23-6 4-chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1292836-16-8 1-(4-chloro-2-fluoro-5-nitrophenyl)ethanone 
• 446-30-0 4-chloro-2-fluorobenzoic acid 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

SUBSTITUTED TETRAHYDROCARBAZOLE AND CYCLOPENTANOINDOLE DERIVATIVES

The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion.