175718-41-9Relevant academic research and scientific papers
Lipase-catalyzed separation of the enantiomers of 1-substituted-3-arylthio- 2-propanols
Wielechowska, Monika,Plenkiewicz, Jan
, p. 1199 - 1205 (2007/10/03)
Optically active (R)- and (S)-1-substituted-3-(arylthio)propan-2-ols have been prepared in the reaction of the appropriate 2-(arylthiomethyl)oxiranes with chloride and azide anions followed by a lipase-catalyzed transesterification. The effects of the enzyme preparation as well as of the reaction conditions have been compared in terms of the enantiomeric excess of the obtained acetate and unreacted alcohol.
Thiazolidine and oxazolidine derivatives, their preparation and their medical use
-
, (2008/06/13)
Compounds of formula (I): STR1 and salts, esters and solyates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.
