17572-09-7

Basic information

• Product Name: FURAN-2-CARBOTHIOAMIDE
• Synonyms: FURAN-2-CARBOTHIOAMIDE;FURAN-2-CARBOTHIOIC ACID AMIDE;Furan-2-thiocarboxamide, 97%;Furan-2-carbothioic acid amide, 2-Carbamothioylfuran, Furan-2-carbothioamide;2-FurancarbothioaMide;Furan-2-carbothioic acid amide, 2-Carbamothioylfuran
• CAS NO: 17572-09-7
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• Product Categories: Furans, Benzofurans & Dihydrobenzofurans;Furans, Benzofurans & Dihydrobenzofurans
• Mol File: 17572-09-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 129-130°C
• Boiling Point: 219.6 °C at 760 mmHg
• Flash Point: 86.6 °C
• Appearance: /
• Density: 1.287 g/cm³
• Vapor Pressure: 0.118mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: FURAN-2-CARBOTHIOAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FURAN-2-CARBOTHIOAMIDE(17572-09-7)
• EPA Substance Registry System: FURAN-2-CARBOTHIOAMIDE(17572-09-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 17572-09-7(Hazardous Substances Data)

Usage

General Description

Furan-2-carbothioamide is a chemical compound with the molecular formula C5H5NOS. It is a member of the furan family and contains a sulfur atom bonded to a carbon atom within a five-membered ring. Furan-2-carbothioamide has been studied for its potential biological activities, including its antimicrobial, antiviral, and antitumor properties. Furan-2-carbothioamide has also been investigated for its potential use in drug development and as a building block in organic synthesis. Overall, this compound shows promise for various applications in the medical and pharmaceutical industries.

InChI:InChI=1/C5H5NOS/c6-5(8)4-2-1-3-7-4/h1-3H,(H2,6,8)

Upstream product

• 609-38-1 furan-2-carboxylic acid amide 
• 4439-57-0 methyl furimidate 
• 98-01-1 furfural 
• 617-90-3 2-furancarbonitrile 
• 1121-47-7 2-furaldehyde oxime 
• 72667-24-4 Brenzschleimsaeurenitril 

Downstream Products

• 117070-04-9 furan-2-carbothioic acid benzylamide 
• 157252-27-2 methyl 7-amino-1-benzofuran-4-carboxylate 
• 319905-68-5 ethyl 2-(furan-2-yl)-4-phenyl-1H-pyrrole-3-carboxylate 
• 1214879-44-3 C₁₅H₁₀ClNO₃S 
• 1233941-53-1 2-(furan-2-yl)-5-phenyl-1,3-thiazol-4-ol 
• 1417902-16-9 4-(4-(((tert-butyl)dimethylsilyl)oxy)-2-(furan-2-yl)thiazol-5-yl)aniline 
• 1417902-12-5 4-(((tert-butyl)dimethylsilyl)oxy)-2-(furan-2-yl)-5-(4-nitrophenyl)thiazole 
• 1417902-08-9 2-(furan-2-yl)-5-(4-nitrophenyl)thiazol-4-ol 
• 77358-58-8 6-(2-Furyl)-3-isopropyl-2-phenyl-2,3-dihydro-4H-1,3,5-thiadiazin-4-on 
• 80784-85-6 6-Furan-2-yl-[1,3,5]thiadiazine-2,4-dione 
• 55484-03-2 2-(2'-furyl)pyridine 
• 159267-51-3 (6R,7S)-7-tert-Butoxycarbonylamino-3-(2-furan-2-yl-thiazol-4-yl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 4208-53-1 2-methyl-1-(2-furyl)-1-propanone 
• 89767-77-1 3,5-bis(furan-2-yl)-1,2,4-thiadiazole 

Relevant articles and documents

Arylthioamides as H2S donors: L-cysteine-activated releasing properties and vascular effects in vitro and in vivo

A small library of arylthioamides 1-12 was easily synthesized, and their H2S-releasing properties were evaluated both in the absence or in the presence of an organic thiol such as l-cysteine. A number of arylthioamides (1-3 and 7) showed a slow and l-cysteine-dependent H2S-releasing mechanism, similar to that exhibited by the reference slow H2S- releasing agents, such as diallyl disulfide (DADS) and the phosphinodithioate derivative GYY 4137. Compound 1 strongly abolished the noradrenaline-induced vasoconstriction in isolated rat aortic rings and hyperpolarized the membranes of human vascular smooth muscle cells in a concentration-dependent fashion. Finally, a significant reduction of the systolic blood pressure of anesthetized normotensive rats was observed after its oral administration. Altogether these results highlighted the potential of arylthioamides 1-3 and 7 as H 2S-donors for basic studies, and for the rational design/development of promising pharmacotherapeutic agents to treat cardiovascular diseases.

Green preparation method for thioamide

The invention discloses a green preparation method for thioamide. According to the method, in the presence of an oxidizing agent and an iodine reagent, a cyano-containing heterocyclic ring, an aromatic hydrocarbon compound and elemental sulfur or thiuram react in a reaction solvent to prepare a thioamide compound. The method is also applicable to other compounds containing cyano groups on sp carbon. The method has the advantages of one-step reaction synthesis, simple operation, mild reaction conditions, broad spectrum, environment friendliness, usage of cheap and easily available raw materials, and good market application prospect. The method solves technical problems in direct thioamidation of cyano-containing pyridine compounds and other cyano-containing heterocyclic and aromatic compounds, and can be used for modification of various cyano-containing pesticides, such as fipronil, ethiprole and the like.

A novel process for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles from aryl nitriles

A novel and efficient process for the synthesis of 3,5-diaryl-1,2,4- thiadiazoles from aryl nitriles in 1-butyl-3-methylimidazolium bromide promoted by (NH4)2S and TCT-DMSO is described.