17572-86-0Relevant articles and documents
Total Synthesis of (?)-Pepluanol B: Conformational Control of the Eight-Membered-Ring System
Chen, Peiqi,Fang, Ran,Li, Huilin,Liu, Meng,She, Xuegong,Wu, Chuanhua,Xie, Xingang,Zhang, Jing,Zhao, Gaoyuan,Zhou, Lin
, p. 3966 - 3970 (2020/02/05)
The first total synthesis of the Euphorbia diterpenoid pepluanol B in both racemic and enantioenriched form involves 20 steps from a known bicyclic diol. This synthesis features an unprecedented bromo-epoxidation to control the eight-membered-ring conform
NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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Page/Page column 62, (2016/06/28)
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
Chiral bicyclo[3.3.0]octa-2,5-dienes as steering ligands in substrate-dependent rhodium-catalyzed 1,4-addition of arylboronic acids to enones
Heibig, Sarah,Sauer, Sven,Cramer, Nicolai,Laschat, Sabine,Baro, Angelika,Frey, Wolfgang
, p. 2331 - 2337 (2008/09/19)
The synthesis of disubstituted chiral diene ligands (3aR,6aR)- and (3aS,6aS)-10 with a pentalene backbone from the corresponding bicyclo[3.3.0]octa1,4-diones 7 is described. The latter were accessible by enzymatic resolution of the racemic diol rac-5 and
