175724-29-5Relevant articles and documents
Multi-arm single-molecular-weight polyethylene glycol and active derivative, preparation and application thereof
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Paragraph 0226; 0227; 0228; 0229; 0230, (2018/11/03)
The invention discloses multi-arm single-molecular-weight polyethylene glycol and an active derivative, preparation and application thereof. The multi-arm single-molecular-weight polyethylene glycol and the reactive derivative thereof are single molecular weight compounds, the application of a high molecular polymer mixture in the prior art is avoided, and the purity of a drug is effectively improved. When applied to drug modification, the multi-arm single-molecular-weight polyethylene glycol and the active derivative thereof can effectively improve the solubility, stability and immunogenicityof the drug, improve the absorption in vivo of the drug, prolong the half-life period of the drug, improve the bioavailability of the drug, enhance the efficacy of the drug, and reduce the toxic andside effects of the drug. Gel formed by the multi-arm single-molecular-weight polyethylene glycol active derivative provided by the invention can be used for preparing a slow release drug, prolongingthe action time of the drug, reducing the frequency of drug administrations, and improving patient compliance.
New polypodal polycarboxylic ligands - Complexation of rare-earth ions in aqueous solution
Viguier, Romain,Serratrice, Guy,Dupraz, Agnes,Dupuy, Claude
, p. 1789 - 1795 (2007/10/03)
The complexation ability of new polypodal carboxylic ligands prepared from 2,2-bis(hydroxymethyl)-1-alkanols was investigated in aqueous solution with Y3+ and various lanthanide ions (La3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+). The values of the stability constants for ML complexes are of the order of 104 for the hexadentate trioxypropionates, 107 for the hexadentate trioxyacetates and 1014 for the nonadentate triaminohexaacetates. In these systems, the nitrogens of the amino groups seem to be better chelating atoms than the oxygens of the ether groups. The hydration numbers of dysprosium(III) complexes have been determined from the DyIII-induced 17O NMR water shifts.