175779-28-9

Basic information

• Product Name: (R)-TaClo
• Synonyms: (S)-1-TrichloroMethyl-1,2,3,4-Tetrahydro-β-carboline;(S)-2,3,4,9-Tetrahydro-1-(trichloroMethyl)-1H-pyrido[3,4-b]indole
• CAS NO: 175779-28-9
• Molecular Formula: C12H10Cl3N2
• Molecular Weight: 288.5802
• Mol File: 175779-28-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-TaClo(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-TaClo(175779-28-9)
• EPA Substance Registry System: (R)-TaClo(175779-28-9)

Safety Data

• Hazardous Substances Data: 175779-28-9(Hazardous Substances Data)

Usage

General Description

(R)-TaClo is a chiral organochlorine compound that is used as a chemical weapon and has been classified as a chemical warfare agent. It is a potent, long-lasting nerve agent that acts by inhibiting the activity of the enzyme acetylcholinesterase, leading to overstimulation of the nervous system and potentially causing death. (R)-TaClo is highly toxic and can be lethal when ingested, inhaled, or absorbed through the skin. It has been developed for use as a weapon due to its potent neurotoxic effects and has been the subject of international scrutiny and concern due to its potential for use in chemical warfare.

Upstream product

• 61-54-1 tryptamine 
• 75-87-6 chloral 

Relevant articles and documents

Investigation on Plasma Levels of the Neurotoxin 1-Tricloromethyl-1,2,3,4-tetrahydro-β-carboline after Oral Administration of Chloral Hydrate in Man

Chloral hydrate (CAS 302-17-0) is a widely used hypnotic and sedative agent.It was recently reported in the literature that a neurotoxin, TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline), may be formed in vitro from tryptamine (Ta) and chloral (Clo).Intraperitoneal administration of TaClo led to Parkinson-like symptoms in the rat.Hence, the plasma levels of TaClo were determined at various time-ponts in 18 healthy volunteers in two periods each during a bioavailability study of several chloral hydrate preparations.The limit of quantitation for TaClo was 5 ng/ml.No TaClo could be determined in the plasma of the various volunteers following administration of human therapeutic doses of chloral hydrate.Hence, it is unlikely that TaClo will be formed in man after application of therapeutic doses of chloral hydrate to patients. - Keywords: CAS 302-17-0; Chloraldurat; chloral hydrate; neurotoxin; TaClo; 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline