175787-68-5

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 175787-67-4 1-((R)-2-Methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 64715-85-1 (R)-2-methoxy-1-phenylethylamine 

Downstream Products

• 175787-62-9 (R)-5-((R)-1-Hydroxy-2,2-dimethyl-propyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 
• 189106-84-1 (R)-5-((R)-1-Hydroxy-tridecyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 
• 189106-85-2 (S)-5-((S)-1-Hydroxy-tridecyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 
• 189106-87-4 (S)-5-((S)-1-Hydroxy-tridecyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 189106-86-3 (R)-5-((R)-1-Hydroxy-tridecyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 502622-07-3 5-(1-Hydroxy-cyclobutyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 
• 175787-58-3 (R)-5-((R)-1-Hydroxy-ethyl)-1-((R)-2-methoxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one 

Relevant academic research and scientific papers

Highly efficient asymmetric access to 1-azaspiro[4.4]nonane skeleton

Vinylogous Mukaiyama aldol type reaction of chiral non-racemic silyloxypyrroles followed by acidic treatment affords an efficient asymmetric access to 1-azaspiro[4.4]nonanes in high diastereoisomeric excess (up to 79%).

Ytterbium triflate-catalyzed reactions of imines with a chiral non- racemic silyloxypyrrole

In the presence of a catalytic amount of ytterbium triflate the reactions of various aromatic imines with a chiral non-racemic silyloxypyrrole proceeded smoothly to afford the corresponding aldol-type adducts in good yields and diastereoselectivities. (C)

Synthesis of aza-muricatacin : An analogue of the bioactive muricatacin an acetogenin of annonaceae

Muricatacin is a hydroxy butanolide extracted from Annona muricata, and has shown cytotoxic activity. The threo and erythro aza-analogues, namely the hydroxy pyrrolidones have been synthesized through two different routes.

Asymmetric routes towards polyfunctionalized pyrrolidines: Synthesis and reactivity of a chiral silyloxypyrrole

Starting from O-protected (R)-(-)-phenylglycinol, chiral silyloxypyrrole 5 was prepared in two steps and its reaction with achiral aldehydes under Mukaiyama's reaction conditions was investigated. Addition occurred at the C-5 position of the pyrrolidine ring with complete lk selectivity (except in the case of acetaldehyde) and a moderate to good diastereofacial (RR vs SS) selectivity.