175791-53-4

Basic information

• Product Name: 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine
• CAS NO: 175791-53-4
• Molecular Formula: C6H4IN3
• Molecular Weight: 245.02053
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 175791-53-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 2.36
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.98±0.20(Predicted)
• CAS DataBase Reference: 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine(175791-53-4)
• EPA Substance Registry System: 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine(175791-53-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 175791-53-4(Hazardous Substances Data)

Usage

General Description

5-Iodo-7H-pyrrolo[2,3-d]pyrimidine is a synthetic chemical compound classified under the pyrrolopyrimidine group. It's known for its use in the research and pharmaceutical fields. This chemical is white or off-white crystalline in nature and is often used as an intermediate in organic synthesis. It's an aromatic heterocyclic compound that is known for its stability and versatility as a building block in organic chemistry. Apart from these, it's mainly used for the manufacture of drugs and other pharmaceuticals, as well as in various chemical research. The compound should be handled carefully due to its potential chemical reactivity.

Upstream product

• 271-70-5 7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 454685-88-2 5-cyanopyrrolo[2,3-d]pyrimidine 
• 1384953-53-0 tert-butyl 5-(1-benzyl-1H-1,2,3-triazol-4-yl)pyrrolo[2,3-d]pyrimidine-7-carboxylate 
• 1384953-47-2 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1596337-25-5 5-iodo-7-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1596335-56-6 2-(4-chlorophenyl)-N-(6-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyrimidin-4-yl)acetamide 
• 1596335-36-2 2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide 
• 1596336-55-8 2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide 
• 1596335-57-7 2-(3,4-dichlorophenyl)-N-{4-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-2-yl}acetamide 

Relevant articles and documents

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acc

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

INHIBITORS OF E1 ACTIVATING ENZYMES

This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.