17583-18-5Relevant academic research and scientific papers
A facile and efficient approach for the synthesis of 3-arylthiazol-2(3H)-one
Zhu, Yue,Wang, Qilin,Luo, Haofan,Wang, Zijuan,Zhang, Guolin,Yu, Yongping
, p. 2066 - 2072 (2019)
A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80 °C at first and then in acidic condition at room temperature, to afford product
Preparation method of 3-substituted-thiazol-2(3H)-one compound
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Paragraph 0039; 0040; 0041; 0042; 0043-0047; 0050; 0051-0059, (2018/11/22)
The invention discloses a preparation method of a 3-substituted-thiazol-2(3H)-one compound. The preparation method sequentially comprises the following steps: performing a reaction on an acyl azide compound and 2,5-dihydroxy-1,4-dithiane in a solvent at 80 DEG C plus or minus 5 DEG C for 18-21h; adding an aqueous sulfuric acid solution into an obtained reaction solution, reacting while stirring, and then filtering to remove a solid; performing a rotary evaporation on a filtrate to remove the solvent, then adding water, extracting by using ethyl acetate, washing an obtained organic layer by using a saturated salt solution, drying, then performing a rotary evaporation to remove the ethyl acetate, and performing silica gel column chromatography on an obtained concentrate to obtain the 3-substituted-thiazol-2(3H)-one compound. By the preparation method, the condition is mild, the yield is high, the posttreatment is convenient, the pollution is less, used raw materials are easy to obtain, and a simple and easily-implemented method is provided for efficiently synthesizing the 3-substituted-thiazol-2(3H)-one compound.
A solvent- and catalyst-free domino reaction for the efficient synthesis of 3-arylthiazolidine-2-thiones under microwave irradiation
Kumar, Sundaravel Vivek,Muthusubramanian, Shanmugam,Perumal, Subbu
, p. 90451 - 90456 (2015/11/10)
A facile synthesis of 4-hydroxy-3-arylthiazolidine-2-thiones through novel domino reactions of aryl isothiocyanates and 1,4-dithiane-2,5-diol under solvent- and catalyst-free microwave irradiation is reported. This highly atom efficient reaction presumabl
