175844-82-3Relevant academic research and scientific papers
Electrophilic 5-endo-trig cyclisations of 2-silyl-3-alkenols. A stereoselective route to polysubstituted tetrahydrofurans
Andrey, Olivier,Ducry, Laurent,Landais, Yannick,Planchenault, Denis,Weber, Valery
, p. 4339 - 4352 (2007/10/03)
Electrophilic 5-endo-trig cyclisations of allylsilanes have been carried out leading to tri- and tetrasubstituted tetrahydrofurans with reasonable yields and excellent diastereoselectivities. A rationalization of both the regio- and the stereoselectivity has been proposed. A silicon group having a thienyl fragment attached to the silicon has also been devised and was shown to be oxidized under both electrophilic and nucleophilic conditions.
