175873-08-2Relevant articles and documents
Process for the preparation of 3-amino-2-oxo-pyrrolidines, novel intermediates and their use
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, (2008/06/13)
The present invention relates to a process for the preparation of γ-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the ge
Process for the preparation of a 2-oxopyrrolidine compound
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, (2008/06/13)
A process for producing a lactam of the formula STR1 wherein 2-bromo-4 chloro butyryl bromide or 2,4-dibromo butyryl bromide is coupled with 4-aminobenzonitrile to produce 4-(2,4-bromobutyrylamino)-benzonitrile, which is combined with sodium hydroxide, po
Process for the preparation of amidino phenyl pyrrolidine β-alanine urea analogs
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, (2008/06/13)
The invention herein is directed to a process for producing a lactam of the formula STR1 from a methionine analog of the formula STR2 by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent. The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl β-alanine urea analogs using such methionine and lactam compounds as intermediates, which β-alanine urea analogs are useful as antithrombotics.