17589-68-3

Basic information

• Product Name: 3-(4-chlorophenyl)-3-oxopropanoic acid
• CAS NO: 17589-68-3
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.6031
• Mol File: 17589-68-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 400.7°C at 760 mmHg
• Flash Point: 196.1°C
• Density: 1.378g/cm³
• Vapor Pressure: 3.85E-07mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 3-(4-chlorophenyl)-3-oxopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-3-oxopropanoic acid(17589-68-3)
• EPA Substance Registry System: 3-(4-chlorophenyl)-3-oxopropanoic acid(17589-68-3)

Safety Data

• Hazardous Substances Data: 17589-68-3(Hazardous Substances Data)

Usage

Melting point

Different sources of media describe the Melting point of 17589-68-3 differently. You can refer to the following data:
1. 178-180°C
Used as an intermediate in synthesis of pharmaceuticals and agrochemicals
Exhibits anti-inflammatory and analgesic properties
Specific uses and applications may vary
2. 178-180°C
Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals
Exhibits anti-inflammatory and analgesic properties
Specific uses and applications may vary depending on context and chemical properties

Upstream product

• 4640-66-8 p-chlorobenzoylacetonitrile 
• 99-91-2 para-chloroacetophenone 
• 22027-53-8 methyl 3-(4-chlorophenyl)-3-oxopropanoate 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 937-20-2 p-chlorophenacyl chloride 

Downstream Products

• 76103-65-6 1-(4-Chloro-phenyl)-2-(1-methyl-pyrrolidin-2-yl)-ethanone 
• 1443207-67-7 C₂₁H₂₀ClNO₅ 
• 1459140-96-5 C₂₃H₁₈ClNO₃ 
• 121194-36-3 1-(4-chlorophenyl)-3,3,3-trifluoro-propan-1-one 
• 99-91-2 para-chloroacetophenone 
• 106552-29-8 1-(4-chlorophenyl)-3,3-diphenylpropan-1-one 
• 26086-60-2 2-azido-4'-chloroacetophenone 

Relevant articles and documents

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids

An efficient method for Cu-catalyzed decarboxylative trifluoromethylation of β-ketoacids to achieve α-trifluoromethyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional-group compatibility.