175911-29-2

Upstream product

• 18342-24-0 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4(1H)-pyridinone 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 52554-33-3 1-(β-D-ribofuranosyl)-4(1H)-pyridinone 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 626-64-2 pyridin-4-ol 

Downstream Products

• 175911-30-5 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyridin-4-one 

Relevant academic research and scientific papers

Synthesis of pyridinone ribonucleoside 3'-O-phosphoramidites and their incorporation into oligoribonucleotides

Protected pyridin-2- and pyridin-4-one ribonucleosides 3 and 9 were synthesized using a one-pot reaction of silylated bases with 1-O-acetyl-tri-O-benzoyl-β-D-ribofuranose (2) in the presence of CF3SO3SiMe3. The nucleosides were converted in 4 steps into 3'-O-phosphoramidites 7 and 11 which were incorporated into hammerhead ribozyme substrates using solid-phase phosphoramidite chemistry.