175916-63-9Relevant academic research and scientific papers
Enantioselective synthesis of the C1-C9 segment of bryostatin by kinetic resolution of racemic β-keto esters
Kaiesse, Markus,Eh, Marcus
, p. 1767 - 1770 (2007/10/03)
The enantioselective synthesis of the C1-C9 segment of bryostatins is described. Racemic β-keto ester 2 was subjected to kinetic resolution. Reduction with baker's yeast establishes two of the three chiral centers. Chemical transformation of the terminal acetylene moiety generates aldehyde 5 which is transformed diastereoselectively to the corresponding alcohol 6 via Sakurai reaction.
