176019-96-8

Upstream product

• 172490-46-9 2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose 
• 22314-39-2 phenylmethyl 2-amino-2-deoxy-α-D-glucopyranoside 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 339316-68-6 benzyl 2-deoxy-2-(2,2,2-trichloro-ethoxycarbonylamino)-α-D-glucopyranoside 

Downstream Products

• 1372616-71-1 1,6-di-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-ethoxycarbonyl)-2-(2,2,2-trichloro-ethoxy-carbonylamino)-α-D-glucopyranoside 
• 1372616-72-2 1,6-di-O-benzyl-4-O-[3,4,6-tri-O-acetyl-2-deoxy-2-(2,2,2-trichloro-ethoxycarbonylamino)-α-D-glucopyranosyl]-3-O-(2,2,2-trichloro-ethoxycarbonyl)-2-deoxy-2-(2,2,2-trichloro-ethoxy-carbonylamino)-α-D-glucopyranoside 
• 1372616-73-3 1,6-Di-O-benzyl-4-O-[3,4,6-tri-O-acetyl-2-acetamido-α-D-glucopyranosyl]-2-acetamido-α-D-glucopyranoside 
• 1372616-70-0 benzyl 2-deoxy-4,6-O-benzylidene-3-O-(2,2,2-trichloro-ethoxycarbonyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-α-D-glucopyranoside 
• 175876-79-6 (2S,4aR,6S,7R,8R,8aS)-6-Benzyloxy-2-methyl-8-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxine-2-carboxylic acid methyl ester 
• 175876-78-5 benzyl 2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside 
• 175876-77-4 benzyl 4,6-O-benzylidene-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside 

Relevant academic research and scientific papers

SYNTHETIC INNATE IMMUNE RECEPTOR LIGANDS AND USES THEREOF

An adjuvant formulation includes a monophosphoryl Lipid A (MPLA) analogue, a Pam3CSK4 analogue, or a muramyldipeptide (MDP) analogue, or combinations thereof. The adjuvant may be formulated in soluble form or in a nanoparticle, such as polylactic glycolic acid nanoparticles. A vaccine formulation comprises the adjuvant formulation and an immunogen. Methods of vaccinating an animal include delivering the vaccine formulation to the animal.

Synthesis of a 3-hydroxyl-free N-acetyl glucosamine disaccharide

A simple and alternative route to a versatile N-acetyl glucosamine disaccharide building block was developed, possessing a free 3-hydroxyl group. In this strategy, the 2,2,2-trichloro-ethoxy carbonyl (Troc) group was used as an amino-and 3-hydroxyl-protec