176040-34-9

Upstream product

• 143-33-9 sodium cyanide 
• 113089-35-3 (1R,8S)-1-mesyloxy-pyrrolizidin-3-one 
• 108910-03-8 (1R,7aS)-1-hydroxytetrahydro-1H-pyrrolizin-3(2H)-one 
• 68-95-1 (S)-acetylproline 
• 161691-20-9 (S)-1-acetyl-N-methoxy-N-methylpyrrolidine-2-carboxamide 
• 150884-75-6 (S)-tetrahydro-1H-pyrrolizine-1,3(2H)-dione 

Downstream Products

• 526-64-7 laburnine 

Relevant academic research and scientific papers

An efficient route to the pyrrolizidine ring system via an N-acyl anion cyclisation process

An enantioselective route to the pyrrolizidine ring system has been developed which uses an N-acyl anion cyclisation reaction as the key step. This methodology has provided the natural pyrrolizidines (-)-(1R, 8S)-1-hydroxy-pyrrolizidine 7, (-)-pyrrolizidin-1-ene-3-one 9 and (±)-trachelanthamidine 14. Extension of the process to an N-propionyl substrate provides ready access to a series of 2-methyl pyrrolizidines.

An asymmetric approach to the pyrrolizidine ring system via N-acetyl and N-propionyl anion cyclisation processes

An efficient route to the pyrrolizidine ring system has been developed. The method, which uses N-acetyl and N-propionyl anion cyclisation reactions as the key steps has provided the natural pyrrolizidines (-)-(1R, 8S)-1-hydroxypyrrolizidine (10), (-)-pyrrolizidin-1-ene-3-one (13), (±)-trachelanthamidine (18) together with a range of 2-methyl substituted pyrrolizidine-3-ones.