17605-00-4Relevant articles and documents
Synthesis of ortho-acylphenols through the palladium-catalyzed ketone-directed hydroxylation of arenes
Mo, Fanyang,Trzepkowski, Louis J.,Dong, Guangbin
supporting information, p. 13075 - 13079 (2013/02/25)
ortho-Acylphenols are an important structural motif found in a diversity of bioactive molecules ranging from natural products to drugs (Figure 1). Moreover, they also serve as versatile building blocks for the synthesis of various pharmaceuticals, such as warfarin, as well as agrichemicals, flavors, and fragrances. Classic approaches to the synthesis of o-acylphenols generally involve a two-step process: acylation of phenols followed by Fries rearrangement of the resulting phenyl esters (Scheme 1a). On the other hand, direct C-acylation of phenols has also been known under more forcing conditions. Although effective, these approaches are often complicated by the formation of undesired p-substituted products when bulky acyl groups need to be introduced, as well as the limited variety of ketones that can be generated.
