176050-48-9Relevant academic research and scientific papers
α-glucosidase and pancreatic lipase inhibitory activities of diterpenes from indian mango ginger (curcuma amada roxb.) and its derivatives
Yoshioka, Yuri,Yoshimura, Naori,Matsumura, Shinichi,Wada, Hiroto,Hoshino, Maya,Makino, Shouhei,Morimoto, Masanori
, (2019)
Enzymatic inhibitions of crude extracts and their constituents from Zingiberaceae against both rat intestinal α-glucosidase and porcine pancreatic lipase were investigated. Structure-activity relationships using their derivatives were also investigated. The rhizomes extract of mango ginger, Curcuma amada showed remarkable inhibitory activity in the screening test. Two natural labdane diterpenes 1 and 2 and a drimane sesquiterpene 3 were major constituents isolated from this hexane extract. Among them, (E)-labda-8(17),12-diene-15,16-dial (1) was the most prominent compound and showed inhibitory activity against both α-glucosidase and lipase. Derivatives 4-10 from compound 1 were prepared and evaluated using inhibitory assays with these enzymes. The reduced derivative 4 maintained α-glucosidase inhibitory activity, but had decreased pancreatic lipase inhibitory activity compared with parent compound 1. Other tested derivatives of compound 1, including acetates 5-7 and oxidative derivatives 8-10, had very weak α-glucosidase inhibitory activity. Most of these compounds showed moderate pancreatic lipase inhibitory activity. However, only sesquiterpene albicanal (3) showed drastically decreased pancreatic lipase activity compared with 1. These findings suggested that molecular size was essential for enzymatic inhibitory activities of these compounds. These results demonstrated that mango ginger may be useful for the prevention of obesity and being overweight.
Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors
Jalaja, Renjitha,Leela, Shyni G.,Valmiki, Praveen K.,Salfeena, Chettiyan Thodi F.,Ashitha, Kizhakkan T.,Krishna Rao, Venkata Rao D.,Nair, Mangalam S.,Gopalan, Raghu K.,Somappa, Sasidhar B.
supporting information, p. 662 - 666 (2018/06/27)
Obesity contributes to the genesis of many metabolic disorders including dyslipidemia, coronary heart disease (CHD), nonalcoholic fatty liver, type 2 diabetes, etc. Pancreatic lipase plays a vital role in food fat digestion and absorption. Therefore, to c
Facile isolation of (E)-labda-8(17),12-diene-15,16-dial from Curcuma amada and its conversion to other biologically active compounds
Sheeja, Alan D. B.,Nair, Mangalam S.
, p. 319 - 324 (2014/05/06)
Curcuma amada Roxb. (Zingiberaceae) rhizomes have been found to be a good source of (E)-labda-8(17),12-diene- 15,16-dial. This has been chemically transformed to other biologically active compounds like aframodial, zerumin A as well as other natural products like (E)-labda-8(17),12-diene-15,16-olide, 15,16-epoxy-8(17),13(16),14-labdatriene and (-)- marginatone. The antimicrobial activity of zerumin A sodium salt as well as other derivatives of the dialdehyde has been established.
