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176161-55-0

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176161-55-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 176161-55-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,1,6 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 176161-55:
(8*1)+(7*7)+(6*6)+(5*1)+(4*6)+(3*1)+(2*5)+(1*5)=140
140 % 10 = 0
So 176161-55-0 is a valid CAS Registry Number.

176161-55-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloro-N-propan-2-yl-1H-benzimidazol-2-amine

1.2 Other means of identification

Product number -
Other names 2-Isopropylamino-5,6-dichlorobenzimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:176161-55-0 SDS

176161-55-0Downstream Products

176161-55-0Relevant articles and documents

Synthesis and antiviral evaluation of halogenated β-D- and -L- erythrofuranosylbenzimidazoles

Gudmundsson, Kristjan S.,Tidwell, Jeffrey,Lippa, Nicole,Koszalka, George W.,van Draanen, Nanine,Ptak, Roger G.,Drach, John C.,Townsend, Leroy B.

, p. 2464 - 2472 (2007/10/03)

A series of 2-substituted benzimidazole D- and L-erythrofuranosyl nucleosides were synthesized and tested for activity against herpesviruses and for cytotoxicity. The D-nucleosides 2,5,6-trichloro-1-(β-D- erythrofuranosyl)benzimidazole (8a) and 2-bromo-5,6-dichloro-1-(β-D- erythrofuranosyl)benzimidazole (8b) were prepared by coupling 1,2,3-tri-O- acetyl-β-D-erythrofuranose (D-6) with the appropriate benzimidazole, followed by removal of the acetyl protecting groups. The 2-isopropylamino (9), 2-cyclopropylamino (10), and 2-mercaptobenzyl (11) derivatives were synthesized by nucleophilic displacements of the C-2 chlorine in the benzimidazole moiety of 8a. The v-nucleoside 4-bromo-5,6-dichloro-2- isopropylamino-1-(β-v-erythrofuranosyl)benzimidazole (17) was prepared by coupling D-6 with the appropriate benzimidazole. The L-erythrofuranosyl derivatives, 5,6-dichloro-2-isopropylamino-1-(β-L- erythrofuranosyl)benzimidazole (21a), its 2-cyclopropylamino analogue (21b), and the 2-isopropylamino analogue (25), were prepared by coupling L-6 with the appropriate benzimidazole. Several of these new derivatives had very good activity against HCMV in plaque and yield reduction assays (IC50 = 0.05-19 μM against the Towne strain of HCMV) and DNA hybridization assays. Very little activity was observed against other herpesviruses. This pattern is similar to the antiviral activity profile observed for the corresponding ribofuranosides 2,5,6-trichloro-1-(β-D-ribofuranosyl)benzimidazole (4a), its 2-bromo analogue (4b), and the 2-cyclopropylamino analogue (4c). In comparison, 8a was 15-fold more active against HCMV than 4a, and 8b was 4- fold more active against HCMV than 4b. The 5,6-dichloro-2-isopropylamino-1- (βL-erythrofuranosyl)benzimidazole (21a) was less active than 4c, which is now in clinical trials for HCMV infection. Both 8a,b had comparable HCMV activity to 4c. Mode of action studies with the v-erythrose analogues established that 8b acted by inhibition of viral DNA processing whereas 9 and 10 may act via a different mechanism. The lack of a 5'-hydroxymethyl group in all members of this series established that antiviral activity occurred without 5'-phosphorylation, a feature required for the activity of most nucleoside analogues.

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