17617-04-8

Basic information

• Product Name: 3-Amino-2-mercaptopropionic acid
• Synonyms: 3-Amino-2-mercaptopropionic acid;Isocysteine
• CAS NO: 17617-04-8
• Molecular Formula: C3H7NO2S
• Molecular Weight: 121.16
• Mol File: 17617-04-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Amino-2-mercaptopropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-mercaptopropionic acid(17617-04-8)
• EPA Substance Registry System: 3-Amino-2-mercaptopropionic acid(17617-04-8)

Safety Data

• Hazardous Substances Data: 17617-04-8(Hazardous Substances Data)

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 134767-82-1 2-oxo-1-oxa-4-thiaspiro <4.4> nonan-3-ylacetic acid 
• 600-05-5 2,3-dibromopropionic acid 
• 98022-54-9 2-bromo-β-alanine 
• 77217-11-9 2-chloro-β-alanine 

Relevant articles and documents

Single nucleotide specific detection of DNA by native chemical ligation of fluorescence labeled PNA-probes

DNA-directed chemical ligations provide the opportunity to diagnose DNA sequences with very high sequence specificity. Fluorescent labels have been attached to reactive probes to enable the homogeneous detection of DNA and RNA. However, it has frequently been found that the attachment of fluorescent labels results in decreases of ligation fidelity. Herein we describe the development of a fluorogenic ligation reaction that provides for 102-fold to perfect sequence selectivity. The reaction is based on the isocysteine-mediated native chemical PNA ligation. It is shown that DNA-induced rate accelerations of ～43.000-fold can be obtained through subtle variations of the ligation conditions. PNA-thioesters and isocysteine-PNA conjugates were labeled with FAM and TMR fluorophores, respectively. For gaining rapid synthetic access, a convenient on-resin labeling approach was developed. A new PNA monomer featuring an Alloc-protected lysine side chain was synthesized and coupled in solid-phase PNA synthesis. In the event of a ligation reaction the two fluorophores are brought into proximity. It is shown that fluorescence resonance energy transfer provides a positive fluorescence signal which is specific for product formation rather than for loss of starting materials. Single base mutations can be detected within minutes and with very high sequence selectivity at optimized conditions.

DENDRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES AS OPHTHALMIC SEALANTS AND LENSES

The present invention provides compositions and methods for sealing a wound and preparing a lens. The methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine-, cysteine-, isocysteine-residue or other nucleophilic group attached to the periphery of the dendrimer: Addition of a compound containing two or more electrophilic groups such as aldehydes, activated esters, or acrylates to the lysine-, cysteine-, or isocysteine-capped dendrimers produces a polymeric compound that can form a seal or a lens. Another aspect of the invention relates to a method of treating disease using the pharmaceutical compositions of the invention. Other aspects of the invention relate to kits for sealing a wound or preparing a lens, delivery devices, and methods for controlling the polymerization of a hydrogel system.