1762-69-2

Basic information

• Product Name: 2-AMINO-5-ETHYL-1,3-THIAZOL-4(5H)-ONE
• Synonyms: 2-AMINO-5-ETHYL-1,3-THIAZOL-4(5H)-ONE
• CAS NO: 1762-69-2
• Molecular Formula: C₅H₈N₂OS
• Molecular Weight: 144.19482
• Mol File: 1762-69-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 196-198 °C
• Boiling Point: 257.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• PKA: 0.59±0.40(Predicted)
• CAS DataBase Reference: 2-AMINO-5-ETHYL-1,3-THIAZOL-4(5H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-ETHYL-1,3-THIAZOL-4(5H)-ONE(1762-69-2)
• EPA Substance Registry System: 2-AMINO-5-ETHYL-1,3-THIAZOL-4(5H)-ONE(1762-69-2)

Safety Data

• Hazardous Substances Data: 1762-69-2(Hazardous Substances Data)

Usage

Structure

Thiazole derivative with a five-membered ring containing a thiazole core

Functional Groups

Amino group ( -\textNH2 ) at position 2
Ethyl group ( -\textC2\textH5 ) at position 5

Applications

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds
Studied for pharmaceutical applications

Pharmacological Properties

Antibacterial
Antifungal
Antitumor

Research Interest

Subject of interest for medical research and drug development

Value in Medicinal Chemistry

Distinct molecular structure and pharmacological properties make it valuable in medicinal chemistry

Upstream product

• 80-58-0 2-Bromobutyric acid 
• 17356-08-0 thiourea 
• 6111-61-1 ethyl(trichloromethyl)carbinol 

Downstream Products

• 26473-48-3 2-mercapto-butyric acid 

Relevant articles and documents

The reactions of ethyl-, vinyl-, and ethynyl(trichloromethyl)carbinols with aqueous amd methanolic potassium hydroxide, thiourea, and cyanamide

The reactions of ethyl(trichloromethyl)carbinol, dimethyl(trichloromethyl)carbinol. (trichloromethyl)vinylcarbinol, ethynyl(trichloromethyl)carbinol, and 1,1,1-trichloro-3-nonyn-2-ol have been studied with the following reagents.Methanolic potassium hydroxide: α-methoxy acids are formed in 70 and 79 percent yields with the ethyl- and vinylcarbinols respectively.Double bond migration to the conjugated position was observed with the vinylcarbinol.Thiourea: substituted 2-imino-4-thiazolidinones are formed in 27 to 66 percent yield with the first three carbinols with double bond migration in the case of the vinylcarbinol.Cyanamide: the saturated carbinols were converted to substituted ethyl 2-imino-4-oxo-1-imidazolidinecarboximidates in 30 to 60 percent yield.Aqueous potassium hydroxide: α-chloro acids were formed from the ethyl- and vinylcarbinols in 23 and 24 percent yields respectively, again with double bond migration in the case of the vinylcarbinol.The results are discussed in terms of the known parallel reactions with phenyl(trichloromethyl)carbinol, and provide information which illustrates the usefulness and defines the limits of certain known synthetic reactions when applied to the alkyl, alkenyl, and alkynyl trichloromethylcarbinols.