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17624-26-9

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17624-26-9 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 14, p. 388, 1949 DOI: 10.1021/jo01155a008

Check Digit Verification of cas no

The CAS Registry Mumber 17624-26-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,2 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17624-26:
(7*1)+(6*7)+(5*6)+(4*2)+(3*4)+(2*2)+(1*6)=109
109 % 10 = 9
So 17624-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H12N2O2/c18-14-12-6-1-2-7-13(12)15(19)17(14)10-8-11-5-3-4-9-16-11/h1-7,9H,8,10H2

17624-26-9 Well-known Company Product Price

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  • Alfa Aesar

  • (L17849)  N-2-(2-Pyridylethyl)phthalimide, tech. 90%   

  • 17624-26-9

  • 5g

  • 338.0CNY

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  • Alfa Aesar

  • (L17849)  N-2-(2-Pyridylethyl)phthalimide, tech. 90%   

  • 17624-26-9

  • 25g

  • 1540.0CNY

  • Detail

17624-26-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-pyridin-2-ylethyl)isoindole-1,3-dione

1.2 Other means of identification

Product number -
Other names 2-[2-(2-pyridinyl)ethyl]-1H-isoindole-1,3(2H)-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17624-26-9 SDS

17624-26-9Relevant articles and documents

-

Paquette

, p. 2870 (1962)

-

The coordination chemistry of fluorescent pyridinyl- and quinolinyl-phthalimide ligands with the {AuI-PPh3} cationic unit

Mullice, Lucy A.,Thorp-Greenwood, Flora L.,Laye, Rebecca H.,Coogan, Michael P.,Kariuki, Benson M.,Pope, Simon J.A.

experimental part, p. 6836 - 6842 (2010/01/06)

The new mono-dentate ligands, 2-(2-aminoethyl)-N-phthalimido-pyridine (L4) and 8-amino-N-phthalimido-quinoline (L6), were synthesised using a solvent-free melt method. These ligands together with L 1-3,5 (3-amino-N-phthalimido-pyridine; 3-aminomethyl-N-phthalimido- pyridine; 4-aminomethyl-N-phthalimido-pyridine; 3-amino-N-phthalimido-quinoline) were then used to access six luminescent AuI complexes of the generic type {Ph3P-Au-Ln}(OTf). X-Ray crystallography has been used to structurally characterise three of the complexes showing that in the cases of L1 and L3 the complexes adopt an approximately linear P-Au-N coordination geometry. However, in the case of the sterically demanding L6 the structure shows distortions within the ligand and deviations from a linear coordination geometry. Solution state 1H and 31P{1H} NMR confirmed that the proposed formulations and coordination modes exist in solution. At room temperature the photophysical studies showed that the emission from each of the six complexes was in the visible region (395-475 nm) and assigned to a ligand-centred fluorescence (τ 10 ns) in each case. The Royal Society of Chemistry 2009.

New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-α production inhibitors

Collin, Xavier,Robert, Jean-Michel,Wielgosz, Gaetane,Le Baut, Guillaume,Bobin-Dubigeon, Christine,Grimaud, Nicole,Petit, Jean-Yves

, p. 639 - 649 (2007/10/03)

This paper describes the synthesis of N-pyridinyl(alkyl)phthalimides related to N-phenyl-4,5,6,7-tetrafluorophthalimides known to be inhibitors of tumour necrosis factor-α (TNFα) production. Pharmacomodulation at the phthalimidic nitrogen led to the selection of two pharmacophoric fragments (2,4-lutidinyl and β-picolyl), allowing significant inhibition of TNFα production (compounds 12 and 17). Variation of the substituents linked to the homocycle of their phthalimide scaffold indicated that high (TNFα production) inhibitory potency could be achieved, notably by 5-fluoro, 4- or 5-nitro, 5-amino and especially tetrafluoro substitution. The most active compound, N-(pyridin-3-ylmethyl)-4,5,6,7-tetrafluorophthalimide (32) (84% inhibition at 10 μM), also produced an anti-oedematous effect in the PMA-induced mouse-ear swelling test. Although less active than dexamethasone, it exerted a marked reduction in ear thickness after oral administration (63% vs. 85% for dexamethasone at 0.2 mM kg-1) and remained efficient after topical application (46% vs. 96% for the dexamethasone). It also induced potent inhibition in the rat carrageenan foot oedema test with an ID50 (0.14 μM kg-1) comparable with that of N-(2,6-diisopropylphenyl)phthalimide (4) (0.15 μM kg-1).

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