176325-80-7Relevant academic research and scientific papers
Formation of heterocycles by the Mitsunobu reaction. Stereoselective ynthesis of (+)-α-skytanthine
Tsunoda,Ozaki,Shirakata,Tamaoka,Yamamoto,Ito
, p. 2463 - 2466 (1996)
Cyanomethylenetributylphosphorane was shown to mediate the dehydrocyclization of diols and amino alcohols to give the corresponding 6-membered O- and N-heterocycles in 90% or better yields. Using the reaction as a key step, (+)-α-skytanthine, a unique mono terpene alkaloid, was synthesized stereoselectively.
