17634-60-5

Basic information

• Product Name: 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl-
• Synonyms: 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl-
• CAS NO: 17634-60-5
• Molecular Formula: C6H9N3O
• Molecular Weight: 139.1552
• Mol File: 17634-60-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 249.2 °C at 760 mmHg
• Flash Point: 104.5 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.0232mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl-(17634-60-5)
• EPA Substance Registry System: 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl-(17634-60-5)

Safety Data

• Hazardous Substances Data: 17634-60-5(Hazardous Substances Data)

Usage

General Description

2(1H)-Pyrimidinone,4-amino-1,5-dimethyl- is a chemical compound with the molecular formula C6H9N3O. It is a derivative of pyrimidinone and is also known as 4-amino-1,5-dimethyl-2-oxo-2,3-dihydropyrimidine. 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl- is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs, including antiviral and antitumor medications. It has also been studied for its potential as a bioactive molecule with various biological activities. The chemical structure of 2(1H)-Pyrimidinone,4-amino-1,5-dimethyl- makes it a versatile intermediate for the production of a wide range of pharmaceuticals and related compounds.

InChI:InChI=1/C6H9N3O/c1-4-3-9(2)6(10)8-5(4)7/h3H,1-2H3,(H2,7,8,10)

Upstream product

• 554-01-8 5-methylcytosin 
• 74-88-4 methyl iodide 
• 54080-90-9 6,8-Dimethyltetrazolo<1,5-c>pyrimidin-5(6H)-one 
• 6220-45-7 4-ethoxy-1,5-dimethyl-1H-pyrimidin-2-one 

Downstream Products

• 1146966-36-0 1-methyl-5-hydroxymethylcytosine 
• 387334-40-9 1-methyl-5-formylcytosine 

Relevant articles and documents

Ring opening photoreactions of cytosine and uracil with ethylamine

The photochemical reactions of cytosine (Cyt) and uracil (Ura) with ethylamine, an analog of the side chain of the amino acid lysine, have been studied. After irradiation of Cyt in aqueous ethylamine at λ = 254 nm, N-(N′-ethylcarbamoyl)-3-aminoacrylamidine (Ia) and N-(N′-ethylcarbamoyl)-3-ethylaminoacrylamidine (Ib) were isolated as products, while irradiation of Ura gave N-(N′-ethylcarbamoyl)-3-aminoacrylamide (IIa) and N-(N′-ethylcarbamoyl)-3-ethylaminoacrylamide (IIb) as products. Studies in which Ia and IIa were incubated with ethylamine at various pH values indicate that Ib and IIb are secondary products produced via thermal reactions of Ia and IIa with ethylamine. Heating of Ia and Ib leads to ring closure with the resultant formation of 1-ethylcytosine; small amounts of 1-ethyluracil are also produced. Heating of IIa and IIb produces 1-ethyluracil as the sole product. Spectroscopic properties were determined for each of these opened ring products, as well as for N-(N′-ethylcarbamoyl)-3-amino-2-methylacrylamidine (III) and N- (N′-ethylcarbamoyl)-3-amino-2-methylacrylamide (IV). Quantum yield measurements showed that Ia was formed with a Φ of 1.6 × 10-4 at pH 9.8, while Φ for formation of IIa was 7.2 × 10-4 at pH 11.5. A profile of the relative quantum yield for formation of Ia, determined as a function of pH, showed that the maximum quantum yield occurs at around pH 9.5; the analogous profile for IIa shows a maximum quantum yield at pH 11.3 and above. Acetone sensitization does not produce Ia in the Cyt-ethylamine system, which indicates that the known triplet state of Cyt is not involved in reactions leading to this opened ring product.

Preparation and properties of N4-alkyl analogues of 5-methyl-2'-deoxycytidine, their 5'-mono- and triphosphates, and N4-alkyl derivatives of 1,5-dimethylcytosine.

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