17635-25-5

Basic information

• Product Name: QUINOXALINE, 6-IODO-2,3-DIMETHYL-
• Synonyms: QUINOXALINE, 6-IODO-2,3-DIMETHYL-
• CAS NO: 17635-25-5
• Molecular Formula: C₁₀H₉IN₂
• Molecular Weight: 0
• Mol File: 17635-25-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: QUINOXALINE, 6-IODO-2,3-DIMETHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOXALINE, 6-IODO-2,3-DIMETHYL-(17635-25-5)
• EPA Substance Registry System: QUINOXALINE, 6-IODO-2,3-DIMETHYL-(17635-25-5)

Safety Data

• Hazardous Substances Data: 17635-25-5(Hazardous Substances Data)

Upstream product

• 20691-72-9 4-iodo-2-nitroaniline 
• 431-03-8 dimethylglyoxal 
• 20289-35-4 5-iodo-2-nitro-aniline 
• 513-85-9 2.3-butanediol 

Relevant articles and documents

Iron-catalyzed one-pot synthesis of quinoxalines: Transfer hydrogenative condensation of 2-nitroanilines with vicinal diols

Here, we report iron-catalyzed one-pot synthesis of quinoxalines via transfer hydrogenative condensation of 2-nitroanilines with vicinal diols. The tricarbonyl (η4-cyclopentadienone) iron complex, which is well known as the Kn?lker complex, catalyzed the oxidation of alcohols and the reduction of nitroarenes, and the corresponding carbonyl and 1,2-diaminobenzene intermediates were generated in situ. Trimethylamine N-oxide was used to activate the iron complex. Various unsymmetrical and symmetrical vicinal diols were applied for transfer hydrogenation, resulting in quinoxaline derivatives in 49-98% yields. A plausible mechanism was proposed based on a series of control experiments. The major advantages of this protocol are that no external redox reagents or additional base is needed and that water is liberated as the sole byproduct. This journal is